Summary of Abstract Submission

Abstract Submission No. IO50-12-0018PresentationPoster


Dr.Pranita Waghmare*1, Dr. Kamalesh Prasad1, Dr. Ramavatar Meena2, Dr. M. R. Rathod2, Shruti Chaterjee 2, Dr. B.C. Harinath 1

1 Department of Biochemistry, JBTDRC, Mahatma Gandhi Institute for , India
2 , India


WHO reported almost 9 million deaths every year due to tuberculosis, a second leading cause of death. Anti tuberculosis drugs introduced and modified in 1980 documenting 98% of cure of the disease by multidrug therapy administering drugs such as streptomycin and other highly specific drugs such as Isoniazid, Rifampicin, Ethambutol etc.,. Present drug strategy has many disadvantages which includes long duration, as a result many of the patients do not adhere to treatment, thus incomplete treatment leading to development of drug. Discovery of novel drug candidates, with minimal side effects from natural products may be good alternative and need to be explored further to the molecular levels. There are many ayurvedic preparations showing properties like antibacterial, antiviral and are non toxic in nature. In this study, we have screened extracts of the halophytic plant, Salicornia Brachiata for antitubercular activity in vitro. Extracts of Salicornia Brachiata, a halophyte has been patented (US 7,989,004 B2) for their anti TB activity. The aqueous extracts of the root of the plant were prepared at CSMCRI, Bhavnagar, Gujarat. Invitro culture studies conducted at Dept. of Biochemistry, JBTDRC, MGIMS, Sevagram to confirm antitubercular activity. Studies have revealed encouraging antimycobacterial activity similar to well known standard antimycobacterial drugs INH and RIF. The data were analyzed and it was inferred that January is the best month for the collection of the halophyte having maximum activity with root extract . Preliminary studies indicated the presence of polyphenols such as flavonoids in the extracts, perhaps responsible for the antitubercular activity.