Summary of Abstract Submission

Abstract Submission No. IO50-09-0044PresentationPoster

ROLE OF SYMBIOTIC MICROORGANISMS OF MARINE SPONGES IN MARINE DRUG DISCOVERY

Dr. Pramod B. Shinde*1

1 Savitribai Phule Pune University, Pune, India

ABSTRACT :

Marine microorganisms, including marine fungi, represent an underdeveloped and potentially prolific source of structurally diverse secondary metabolites. In addition, some of the bioactive compounds isolated from marine invertebrates were suggested to be produced by fungi associated with them. In our search for cytotoxic metabolites from marine microorganisms, the sponge-derived fungi Paecilomyces lilacinus (family: Trichocomaceae, order: Eurotiales), isolated from a marine sponge Petrosia sp., was investigated. The genus Paecilomyces is a cosmopolitan filamentous fungus, and the strain Paecilomyces lilacinus has been isolated from a wide range of habitats including cultivated and uncultivated soils, forests, grassland, deserts, and sewage sludge as well as from nematode eggs and occasionally from females of root-knot and cyst nematodes. In addition, it has frequently been isolated from the rhizosphere of many crops. This fungus was also isolated from a marine source, mullet gut. Polysaccharides constituted of glucose and galactose, and peptidal antibiotics (P168 and leucinostatin A) have been reported from Paecilomyces lilacinus. Alpha-pyrones and cyclohexenones were isolated along with known analogues from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data.